Course ID: | GENE 8930. 3 hours. |
Course Title: | Advanced Molecular Genetics |
Course Description: | The molecular mechanisms of gene action in procaryotes and eucaryotes, including discussions of chromosome structure and replication, mutagenesis and DNA repair, recombination mechanisms, transposition, transcriptions, and translation controls. |
Oasis Title: | ADV MOL GN |
Semester Course Offered: | Offered fall semester every year. |
Grading System: | A-F (Traditional) |
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Course Objectives: | Students will master topics in advanced molecular genetics through lectures
by research faculty and through reading and discussion of selected research papers
from the primary literature. The successful student will understand general
concepts and mechanisms of molecular genetics, as well experimental approaches
used in contemporary molecular genetics research. The successful student will
understand how to formulate and test hypotheses drawn from concepts of molecular
genetics, and be able to understand, interpret and evaluate published experimental
data. Students will be evaluated on the basis of written examinations and
participation in class discussions. |
Topical Outline: | 1. Transcriptional regulation - prokaryotes
2. Yeast genetics
3. Cell cycle - yeast
4. Meiosis - yeast
5. Yeast mating type switching
6. Prions
7. RNA splicing - eukaryotes
8. RNA localization - eukaryotes
9. Posttranscriptional regulation - eukaryotes
10. Cell-cell signaling
11. Behavioral genetics
12. Cell cycle
13. Plant genetics
14. Gene silencing and position effects - plants
15. Co-suppression - plants
16. Mammalian genetics - genome mapping
17. Manipulating the mouse genome
18. Genetic modifiers
19. Gene expression and chromatin structure
20. Gene silencing and position effects - flies and mice
The course syllabus is a general plan for the course; deviations announced to the
course by the instructor may be necessary. |
Honor Code Reference: | All academic work must meet the standards contained in "A Culture of Honesty". Each
student is responsible to inform themselves about those standards before performing
any academic work. |