Course ID: | PBIO(BINF) 8350-8350L. 3 hours. 2 hours lecture and 2 hours lab per week. |
Course Title: | Molecular Phylogenetics and Evolution |
Course Description: | Students will be introduced to a variety of comparative
approaches for elucidating the evolution of species,
populations, and molecules. Methods for phylogenetic,
population genetic, and molecular evolutionary analyses will be
covered with examples drawn from the primary literature.
Computer labs will train students in the use of state-of-the-
art analysis software. |
Oasis Title: | Molecular Phylo and Evolution |
Prerequisite: | Permission of major or permission of department |
Semester Course Offered: | Offered spring semester every year. |
Grading System: | A-F (Traditional) |
|
Course Objectives: | Since Darwin and Haeckel published their iconic tree figures
some 150 years ago, phylogenetic analyses have provided a
historical framework for interpreting the evolution of form and
function. In recent years, phylogenetic inference has come to
play a central role in Ecology, Genetics, Genomics and
Molecular Biology.
The primary aim of this course is to provide students with the
training and experience necessary to frame, execute and
correctly interpret phylogenetic, comparative and molecular
evolutionary analyses relating to their own research. We will
draw on review papers and the primary literature to learn how
phylogenetically-based comparative studies can be used in
retrospective investigations of a wide range of biological
processes. Readings will be posted on the course website. The
lab will provide students with hands-on training in state-of-
the-art methods of phylogenetic inference.
Throughout the course, students will have opportunities to
analyze their own data or data compiled to address their
specific research interests. This work will culminate in an
original term project. |
Topical Outline: | Introduction to Phylogenetics
Multiple sequence alignment
Maximum parsimony
Distance analysis
Maximum likelihood
Bayesian inference
Coalescence-based species tree estimation
Estimating divergence times and rates of sequence evolution
Phylogeography
Phylogenetically-based inference of character evolution
Molecular evolution
Phylogenomic analysis pipelines |
Honor Code Reference: | All academic work must meet the standards contained in "A Culture of Honesty."
Each student is responsible to inform themselves about those standards before
performing any academic work. |