Course Description
Practical, theoretical, and instrumental aspects of 1D and 2D NMR spectroscopy, including pulsed Fourier transform techniques, proton and carbon-13 techniques used in the analysis of organic compounds and macromolecules. Instrumentally, the focus is on the operation of NMR spectrometers presently available at the University of Georgia.
Athena Title
NMR Spectroscopy
Prerequisite
BCMB 8010 or permission of department
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
This course is intended to provide a practical background in the fundamental principles underlying nuclear magnetic resonance (NMR) and to provide practical experience in data acquisition and analysis. The focus is on small organic molecules but other types of molecules including biological macromolecules are discussed. Material is presented partly in lecture and partly in laboratory formats. Upon successful completion of the course, a student will understand the NMR phenomenon, will understand how it can be used to understand molecular structure and dynamics, will be able to acquire and interpret data for the fundamental types of NMR analyses. This course will also serve as a prerequisite to more advanced courses offered in biomolecular NMR as well as other application-oriented courses.
Topical Outline
Basic Principles 1H and 13C Chemical Shifts 1H/1H, 13C/1H, 13C/13C Couplings 1D 1H and 13C NMR 1D Double Resonance NMR Complex 1D Pulse Sequences (Spin-Echo, INEPT, DEPT) 2D NMR 2D NMR Pulse Sequences (COSY, TOCSY, HETCOR, HSQC) The Nuclear Overhauser Effect (NOESY)
Syllabus
Public CV