Course Description
The rational basis for drug design, discovery, and development, as well as the chemical and physical basis for drug action will be discussed. Topics will include structure-activity relationships, organic synthesis, organic mechanisms, mechanisms of action, metabolism, toxicity, computer-assisted drug design, case studies, history, and other fundamental topics.
Athena Title
Chem Drug Design and Drug Act
Prerequisite
(CHEM 2212 or CHEM 2312H or CHEM 2412) and BCMB 4010/6010
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Course Objectives
CHEM 4120 LEARNING OBJECTIVES: A. Apply fundamental concepts from organic chemistry towards the understanding of drug activity and design. B. Understand the important scientific discoveries that have lead to the development of modern drug design. C. Find/Research information on drug activity/design utilizing the primary literature and secondary sources such as the Internet. D. Critically and ethically evaluating information on Drug Activity/Design. E. Write a term paper in appropriate scientific style, covering the development and activity of a selected drug. F. Students will use Powerpoint and/or other presentation technologies to present their term papers in an oral presentation.
Topical Outline
CHEM 4120 TOPICS: I. Drug Discovery, Design and Development: Case Studies II. Structures of macromolecules: Proteins, Carbohydrates and Nucleic Acids, Lipids and Membranes III.Receptors: Functional selectivity in receptors IV. Enzymes, Enzyme Inhibition and Inactivation IV. DNA-Interactive Agents V. Drug Metabolism VI. Prodrugs and Drug Delivery Systems VII.Class Presentations (on student-selected drugs)
Syllabus