The rational basis for drug design, discovery, and development, as well as the chemical and physical basis for drug action will be discussed. Topics will include structure-activity relationships, organic synthesis, organic mechanisms, mechanisms of action, metabolism, toxicity, computer-assisted drug design, case studies, history, and other fundamental topics.
Additional Requirements for Graduate Students: The graduate student exams will be longer and feature more complex questions. The final paper length and scope will be doubled, from 5 pages to 10 pages.
Athena Title
Chem Drug Design and Drug Act
Prerequisite
(CHEM 2212 or CHEM 2312H or CHEM 2412) and BCMB 4010/6010
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Student learning Outcomes
At the end of the course, students will be able to apply fundamental concepts from organic chemistry towards the understanding of drug activity and design.
At the end of the course, students will be able to explain the important scientific discoveries that have led to the development of modern drug design.
At the end of the course, students will be able to utilize the primary literature and secondary sources to find information on drug activity/design.
At the end of the course, students will be able to critically and ethically evaluate information on Drug Activity/Design.
At the end of the course, students will be able to write a paper in appropriate scientific style over topics from the primary literature.
At the end of the course, students will be able to use PowerPoint and/or other presentation technologies to give an oral presentation.
Topical Outline
I. Drug Discovery, Design, and Development
II. Structures of macromolecules: Proteins, Carbohydrates and Nucleic Acids, Lipids and Membranes
III. Receptors: Functional selectivity in receptors
