Course Description
The basic science and clinical issues associated with the pathogenesis and pharmacological management of major neurologic and psychiatric diseases suffered by humans.
Athena Title
ADV THER II
Prerequisite
Permission of department
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
Students will be able to comprehend and describe: 1) The cellular and molecular mechanisms of neurotransmission. 2) The role of a range of neurotransmitters and their receptors in normal physiologic processes and disease. 3) Principles of drug action at sites of neurochemical signal transduction. 4) Clinical signs and symptoms of the major CNS disorders. 5) General pathophysiology of major neurologic and psychiatric illnesses. 6) Current research approaches to the therapy of neurologic and psychiatric illnesses. 7) Potential avenues of drug development including the use and generation of animal models as well as invitro techniques.
Topical Outline
I. Introduction Overview of Course Student Expectations Exams II. Cellular Neuroscience Neuronal Cell Features Membrane Polarity Axonal Transport Synaptic Transmission Receptor Theory and Signal Transduction Ion channels Second Messenger Coupled Receptors Mathematical Models Neurotransmitters and Neuromodulators Long Term Potentiation Long Term Depression Neurodegeneration III. Anatomical Pathways/Neuronal Circuits Learning and Memory Movement Pain Emotion Central Cardiovascular Control IV. Animal Models and Experimental Paradigms Learning and Memory (Dementia) Rodent Non-Human Primate Movement Disorders (Parkinsonism) Nociception Depression Seizures Stroke V. Clinical and Experimental Therapeutics Each Lecture in Section V will cover: Epidemiology of the Disease Clinical Symptoms Pathophysiology Clinical Therapeutics Experimental Therapeutics and Drug Development Topics: Dementia Movement Disorders Pain and Headache Seizure Disorders Stroke Psychoses Affective Disorders Anxiety Disorders
Syllabus
Public CV