A focus on the remarkable impact that genome sequencing projects
is having on virtually all aspects of biochemistry, as well as on
medicine and biotechnology. An introduction to a broad range of
'omic' topics, including functional genomics, microarrays,
proteomics, physiological genomics, and bioinformatics.
Athena Title
Genomics and Bioinformatics
Prerequisite
BCMB(BIOL)(CHEM) 3100 or BCMB 4010/6010
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Student Learning Outcomes
Students will explain how the genome sequences of microbes, of humans and of environments, are determined.
Students will describe how genome sequence information is used to provide insights into how a human cell functions, which diseases a human is susceptible to and how this is affected by interactions with microbes, and how the human species evolved.
Students will describe how DNA is used to create synthetic life and to produce long term data storage systems.
Students will solve problems using bioinformatics tools and techniques including sequence comparison, structure modeling, and multimodal data analysis.
Students will perform practical bioinformatics analyses using real biological datasets.
Students will visualize and interpret biological data to generate a hypothesis or to a conclusion.
Students will integrate diverse biological data types for protein and gene function prediction.
Students will delineate the various ways that gene expression is regulated.
Students will explain how basic research discoveries can lead to revolutionary biotechnologies.
Students will design hypothetical experiments that apply biotechnologies to address problems
Topical Outline
Topics include genome projects, genome sequencing and annotation, gene expression and the transcriptome, proteomics, functional genomics, SNPs, metabolomics, and computational
genomics. An outline of the syllabus is as follows:
1. Genome Projects: Organization and Objectives
- Genome Science
- The Human Genome Project
- Animal Genomes
- Plant Genomes
- Other Genome Projects
2. Genome Sequencing and Annotation
- Sequencing Methods
- Genome Annotation
- Functional Annotation
- Gene Family Clusters
3. Gene Expression and the Transcriptome
- Methods for Gene Expression Analysis
- Single Gene Analysis
- Properties of Transcriptomes
4. Proteomics and Functional Genomics
- Functional Proteomics
- Structural Proteomics
- Functional Genomics
5. SNPs and Variation
- Single Nucleotide Polymorphisms
- SNP Technology
- Genotyping
6. Integrative Genomics
- Metabolomics
- In silico Genomics
Institutional Competencies
Analytical Thinking
The ability to reason, interpret, analyze, and solve problems from a wide array of authentic contexts.
