Course Description
Basic concepts associated with drug absorption, distribution, metabolism, excretion, and transport with an emphasis on compartmental modeling related to dosing of drugs. Specific disease states that alter drug disposition.
Additional Requirements for Graduate Students:
Graduate students will be assigned readings which will be
discussed at a separate group session each week. In addition,
graduate students will have an additional take-home section for
each examination.
Athena Title
Biopharm and Pharmacokinetics
Prerequisite
PHRM 4200/6200 and PHRM 3300
Corequisite
PHRM 4040
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Course Objectives
1. Understand basic concepts associated with drug absorption, distribution, metabolism, excretion and transport. 2. Calculate and interpret pharmacokinetic parameters. 3. Predict drug interactions and be able to explain the mechanism(s) involved. 4. Determine when to obtain blood levels and how to interpret the blood levels 5. Determine the effects of renal, hepatic and cardiovascular disease on pharmacokinetics of drugs 6. Examine pharmacokinetics in special populations 7. Examine the influene of pharmacogenomics on pharmacokinetics/pharmacodynamics
Topical Outline
Principles of drug absorption, distribution, metabolism, excretion, and transport Compartmental modeling Drug interactions Pharmacodynamics Pharmacokinetic basis for dosing of drugs Influence of disease states on pharmacokinetics Dosing adjustments in disease states and hemodialysis Pharmacokinetics in geriatric and pediatric patients Pharmacogenomics and clinical implications
Syllabus