Course Description
Molecular mechanisms of toxicities.
Athena Title
MOLECULAR TOX
Prerequisite
(PHRM(VPHY) 6910 and BCMB 4010/6010 and BCMB 4020/6020) or (BCMB 8010 and BCMB 8020)
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Course Objectives
The objective is to enable the students to gain in-depth knowledge about the molecular mechanisms of toxicities through studying real cases. Students will learn how the toxicities happen and how to analyze toxicities from the molecular aspect.
Topical Outline
1. Xenobiotic metabolic activation and deactivation: Cytochrome P450s, Glutathione transferases, Superoxide dismutases, Sulfotransferase; Oxidation, Epoxidation, Hydrolysis; Transcriptional gene regulation. 2. Mutagenesis and carcinogenesis: Mutagens, carcinogens; Genomic instability, DNA damage, DNA repair, Cell cycle checkpoints, Apoptosis; Oncogenes, Tumor suppressor genes. 3. Receptor-mediated toxicity: Nuclear receptors - Aryl hydrocarbon receptor (AHR), Estrogen receptors (ERs), Androgen receptor (AR), Peroxisome proliferator-activated receptor a and y (PPARa and PPARy); Transmembrane receptors - G protein- coupled receptors (GPCRs, such as Muscarinic acetylcholine receptor (mAChR), Adrenergic receptors, y-aminobutyric receptor B (GABAB), Monoamine receptors), ligand-gated ion channels (such as Nicotinic acetylcholine receptor (nAChR), GABAA, GABAC).