This course deals with the application of structure and theory to the study of organic reaction mechanisms: stereochemical features including conformation and stereoelectronic effects; reaction dynamics, isotope effects and molecular orbital theory applied to pericyclic and photochemical reactions; and special reactive intermediates including carbenes, carbanions, and free radicals.
Athena Title
Advanced Organic Chemistry III
Prerequisite
CHEM 2212 or CHEM 2312H or CHEM 2412
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Student Learning Outcomes
At the conclusion of this course students will describe the importance of absolute and relative molecular stereochemistry in a molecule's function and formulate synthetic strategies to ensure the desired stereochemistry is produced, including methods of asymmetric catalysis.
At the conclusion of this course students will utilize protecting group strategies in multistep synthesis.
At the conclusion of this course students will apply the principles of retrosynthesis and formulate multistep syntheses of complex molecules.
At the conclusion of this course students will write reasonable reaction mechanisms substitution, elimination, enolate, radical, and pericyclic reactions.
At the conclusion of this course students will identify peer-reviewed journals for organic chemistry research and be able to read, comprehend, and summarize articles of primary literature for organic chemistry.
Topical Outline
1. Stereochemistry
2. Elucidating reaction mechanisms
3. Free radical reactions
4. Photochemistry
5. Carbenes
6. Total Synthesis
7. Introduction to heterocycles/Pyridine, Pyrrole, Azoles, Indoles, and Other Important Aromatic Heterocycles
8. Synthesis/Chemistry of Industrially Imported Heterocycles
9. Biosynthesis of Heterocycles
Institutional Competencies
Analytical Thinking
The ability to reason, interpret, analyze, and solve problems from a wide array of authentic contexts.
Critical Thinking
The ability to pursue and comprehensively evaluate information before accepting or establishing a conclusion, decision, or action.
