General human pharmacological principles and specific therapeutic actions of major drug classes commonly used in clinically significant disease states.
Additional Requirements for Graduate Students: Graduate students will be administered different examinations/assignments that will require them to demonstrate greater critical thinking skills by applying concepts from the course in the design and interpretation of experiments.
Athena Title
Human Pharmacology
Equivalent Courses
Not open to students with credit in PMCY 4800H
Prerequisite
[(BCMB 3100 or BCMB 3100E or BCMB 3100H) and (PMCY 4020/6020 or PMCY 4020E/6020E or PMCY 4020H)] or permission of department
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Student learning Outcomes
Students will develop an understanding of the molecular and organ system basis for the therapeutic use of the major classes of drugs in humans for the treatment of disease.
Students will understand the mechanism of action of major classes of therapeutics in clinically significant disease states.
Students will be able to integrate physiology, disease, drug action, and toxicology into a holistic model of patient treatment.
Topical Outline
1) Fundamental Principles
a) Pharmacodynamics
i) Receptor classes
ii) Dose-response curves
b) Pharmacokinetics
i) ADME
c) Toxicology
i) Adverse effects
ii) Drug safety and screening
iii) Therapeutic effects of chemotherapeutics
2) Autonomic Pharmacology
a) Neurotransmitter function and regulation
b) Cholinergic transmission overview
i) Major transmitters, receptors, and physiologic effects
ii) Therapeutic use of cholinergic activators and inhibitors
c) Adrenergic transmission overview
i) Major transmitters, receptors, and physiologic effects
ii) Therapeutic use of adrenergic activators and inhibitors
3) Therapeutics that target the Cardiovascular System:
a) Anti-hypertensives
b) Angina therapeutics
c) Heart Failure therapeutics
d) Anti-Arrhythmia
e) Diuretics
4) Therapeutics that target the Central Nervous System:
a) Sedatives
b) Anti-seizure drugs
c) General anesthetics
d) Local anesthetics
e) Muscle relaxants
f) Anti-Parkinsonism drugs
g) Anti-Psychotics
h) Anti-depressants
i) Analgesics
5) Therapeutics that target the Circulatory and Inflammatory systems:
a) Anti-histamines
b) Anemia
c) Anti-inflammatories
d) Anti-coagulants
6) Therapeutics that target the Endocrine Systems:
a) Hypothalamic and pituitary hormones
b) Thyroid hormones
c) Corticosteroids
d) Pancreatic hormones
e) Gonadal hormones
7) Chemotherapeutics
a) Anti-bacterials
b) Anti-virals
c) Anti-fungals, anthelmintic, antiprotozoal, etc.
d) Cancer chemotherapy
