Course Description
Biopharmaceutical and pharmacokinetic principles with an emphasis on evaluation of dosage formulations and drug development.
Additional Requirements for Graduate Students:
Graduate students will be assigned a contemporary topic beyond
the typical content of the course. They will have to
independently research this topic and prepare an informative
lecture on this topic for the class.
Athena Title
Pharmkinetics & Pharmdynamics
Prerequisite
[PMCY 2020 and (MATH 2250 or MATH 2250E)] or permission of department
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
This course will cover the major physiochemical and biological factors controlling the absorption, distribution, metabolism and excretion of therapeutics. The role of various dosage forms in altering these parameters will also be discussed. Biopharmaceutical and pharmacokinetic principles will be discussed with an emphasis on quantitative evaluation of dosage formulations and drug development process.
Topical Outline
Dosage Formulations and Drug Absorption Bioavailability and Bioequivalence Drug Distribution Drug Metabolism Drug Transport: Absorption, Distribution and Elimination Drug Excretion Compartment Model Kinetics Non-Compartmental Analysis Computer Analysis of Data Design of PK Studies for Investigational Compounds Small Molecule vs. Large Molecule Therapeutics Pharmacogenomics
Syllabus