Course Description
Foundational and advanced topics in pharmaceutical and biopharmaceutical sciences focusing on physiochemical properties of drugs, delivery systems, and factors influencing the ADME of drugs.
Athena Title
Adv Pharmaceut Biopharmaceut
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
To provide students with a broad knowledge base in biopharmaceutical principles that are essential in the drug development process. Upon completion of the course, the student should be able to: 1) understand the essentials of thermodynamics, states of matter, and physicochemical properties of drugs and excipients as they relate to the pharmaceutical sciences. 2) Understand the principles of drug delivery,targeting, and application of biomaterials and nanotechnology in the development of novel drug delivery systems. 3) understand the physiological and cellular determinants to drug action.
Topical Outline
Solubility/dissolution Phase transitions solid state (polymorphism, hydrates, crystallinity) Partitioning Controlled drug release Targeting Biomaterials Lipid-based drug delivery systems (liposomes, lipid nanoparticles) polymer-based drug delivery systems (micelles, microspheres) Macromolecule (DNA, protein) drug delivery systems Physical and biological barriers for drugs to reach their target Drug absorption Drug metabolism (Phase-I, -II, and -III Elimination) Drug transporters Regulation of drug metabolism and transport