Course Description
Central nervous system drugs, including their physio-chemical properties, structure-activity relationships and toxicities, side effects, and drug interactions.
Athena Title
Medicinal Chemistry II
Prerequisite
PHRM 3070
Corequisite
PHRM 4430 and PHRM 4030
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
The purpose of the course is to cover how the structure of a drug substance affects the Absorption, Distribution, Metabolism, and Elimination(ADME) of the drug, the mechanism of action of the drug, activity and/or potency of the drug and the chemical stability of the drug. In addition, adverse drug reactions and side effects of the covered agents will be presented and, where possible, how structure influences these effects. These items will be covered for each of the drug classes listed in the topical outline. The student should be able to: 1. Identify the drug or drug class given the structure of the drug or a drug prototype 2. List the indications for a drug or drug class 3. Discuss of the characteristics of drug-drug, drug-food, drug-lab or drug-disease interactions given a drug or set of drugs 4. Discuss the side effects of a given drug and the mechanism of these side effects 5. Describe the mechanism of action and the pharmacological action of a given drug or drug class 6. Describe the physicochemical (biological stability) and pharmaceutical (chemical stability) properties of a given drug or drug class 7. Describe the structure-activity relationship for a given drug class 8. Describe the ADME characteristics of a given drug or class 9. Describe how physiological and pathophysiological conditions affects the Absorption, distribution, metabolism and elimination(ADME) of a drug 10.Describe how other drugs influence the ADME characteristic of a given drug
Topical Outline
1. Personalized Medicine 2. Steroids 3. Thyroid Drugs 4. Diabetes 5. Proteins as Drugs and Monoclonal Antibodies 6. Bisphosphonates 7. Prostaglandins, Thromboxanes 8. General and Local Anesthetics 9. Benzodiazepines 10. Diuretics 11. ACE Inhibitors and Angiotensin Receptor Antagonist 12. Anti-arrhythmic, Nitrates, and Other Anti-anginal Drugs 13. Cardiac Glycosides 14. Lipid Lowing Agents 15. Clotting and Anticoagulants and Clot Busters
Syllabus