Course Description
Chemistry, spectrum of activity, stability, incompatibilities, and toxicities of agents used in the treatment of infectious diseases and cancers and the general aspects of anti-infectious disease agent use.
Athena Title
ID and Antitumor Agents
Corequisite
PHRM 4040
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Course Objectives
For the drugs used in Infectious Disease 1. Identify a drug based on its chemical structure as an antibacterial, antifungal, or antiviral agent 2. Given the structure of a drug, identify structural features which are: a) necessary for activity b) important in the chemical stability and resistance to bacterial degradation enzymes c) important to other biopharmaceutical aspects, such as absorption, distribution, metabolism, half-life, and elimination 3. Discuss the major toxicities and side effects and potential drug-drug, drug-food, and drug-lab test interactions 4. Describe a drug’s general spectrum of activity, (e.g., Gram positive, Gram negative) or specific spectrum of activity (e.g., anti-pseudomonal, anti-staphylococcal) 5. Describe the mechanism of action of the agent(s) based on drug class For the drugs used in the treatment of Cancer 1. Describe the mechanism of action of the agents presented 2. Classify the agents as to alkylating agent, antitumor antibiotic, antimetabolite, etc. 3. Identify the major toxicities of the agents and manifestations of the toxicities 4. Describe the metabolic and biochemical activation pathways for the agents presented 5. Identify the major use of the agents presented
Topical Outline
For the Infectious Disease Section • Antibacterials: sulfonamides; dihydrofolate reductase inhibitors; nitrofurans, quinolones; fluoroquinolones; metronidazole. • Antibiotics: penicillins; cephalosporin; carbapenems; monobactams; aminoglycosides; macrolides; clindamycin; tetracyclines; vancomycin; anti-mycobacterium agents. • Antifungals: amphotericin; flucytosine; azoles; triazole; griseofulvin; allylamines • Antivirals: nucleoside reverse transcriptase inhibitors; non- nucleoside reverse transcriptase inhibitors; HIV protease inhibitors; anti-herpetic agents; miscellaneous antiviral agents. For the Anti-Cancer Agents Introduction to cancer chemotherapy Alkylating agents Antitumor antibiotics Antimetabolites Plant-derived agents Drugs affecting hormones Immunomodulators and suppressants
Syllabus
Public CV