Course Description
Pharmacogenomics is rapidly evolving with numerous drugs applicable only to a specific patient population. In addition, emerging trends exhibit a major shift towards precision medicine. In this regard, avoiding unnecessary adverse events and tailoring appropriate medications to patients is a critical part of administering medication. There are more than 150 drugs with pharmacogenomic drug labeling.
Athena Title
Pharmacogenomic Therapies
Prerequisite
PHRM 3550 and PHRM 4880
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
Terminal objectives At the conclusion of this course, students are expected to understand and describe the following: 1. Compare and contrast the use of a drug with pharmacogenomic information on the manufacturer’s drug label to one without such specific guidelines 2. Understand how a pharmacogenomic biomarker and specific drug epitomizes "precision" medicine 3. Be able to cite at least one example of a pharmacogenomics therapy for a condition relating to rheumatology, oncology, cardiology, gastroenterology, endocrinology, psychiatry, or infectious disease 4. Explain one advantage of having a biomarker approved as a "companion diagnostic" in combination with a new drug 5. Cite an example where patient/disease genetics are necessary to tailor the right drug for the condition
Topical Outline
Introduction to pharmacogenomic therapies Understanding the role of genetics in drug response Consumer genetic testing and counseling Genetic effects on metabolism A primer on molecular genetics Overview of the >160 drugs with pharmacogenomic information in drug labeling Precision medicine – drug usage and indication Anticancer Therapeutics Psychiatric Therapeutics Infectious Disease Other conditions: cardiology, rheumatology, and gastroenterology Variability of Clinical Response Genotype-specific drug dosing Mechanisms of drug activity Drug metabolism and alterations in therapy The important role of CYP450 enzymes Risk of adverse events Precautions Contraindications Boxed warnings
Syllabus