Course Description
Designed to train students on three principal objectives which
comprise the second and third stages of a drug discovery
pipeline. Beyond its own course objectives, this course also
serves as the first of three two-credit courses in a series that
encompass aspects of the drug discovery pipeline.
Athena Title
Robotic Tech in Drug Discovery
Non-Traditional Format
This course will be taught 95% or more online.
Grading System
A - F (Traditional)
Student learning Outcomes
- 1. Students will be familiar with lead discovery processes and be able to identify suitable drug targets for lead discovery
- 2. Students will be familiar with the drug discovery pipeline and be able to identify the technical and individual components of each phase.
- 3. Students will be familiar with the technical approaches used to facilitate high-throughput screening (HTS) for drug discovery.
- 4. Students will be able to successfully program a TECAN Freedom EVO 100 robotic liquid handling robot to screen chemical libraries using established assays.
- 5. Students will be able to analyze data through screening to identify positive hits for further analysis.
- 6. Students will be able to design assays to validate positive hits and identify false positives.
Topical Outline
- Module I. Modern Lead Discovery and the Drug Discovery Pipeline
- Module II. Introduction to Liquid Handling Robot Technology
- Module III. Basic Evoware Programming
- Module IV. Intermediate Evoware Programming
- Module V. Assays in an HTS Environment and Putting it All Together
- Module VI. Cheminformatics and Hit Validation
Institutional Competencies Learning Outcomes
Analytical Thinking
The ability to reason, interpret, analyze, and solve problems from a wide array of authentic contexts.
