Biochemical engineering concepts related to large-scale animal
cell biotechnology and scalable manufacturing of cellular
products, such as recombinant proteins, monoclonal antibodies,
viral vaccines, therapeutic cells, and gene therapy vectors.
Working in small groups, students will address a range of
contemporary problems.
Additional Requirements for Graduate Students: Graduate students are required to write a 2000-word bioethics
essay.
Athena Title
Animal Cell Biomanufacturing
Non-Traditional Format
The Cellular Biomanufacturing course will be taught through
problem-based learning. The class will be given a problem
statement and over the course of four weeks will be expected to
formulate a problem resolution. At the end of each problem
cycle, each group will submit a technical document and give a
short presentation to the class.
Undergraduate Prerequisite
BCHE 3520
Graduate Prerequisite
Permission of department
Semester Course Offered
Offered every year.
Grading System
A - F (Traditional)
Student Learning Outcomes
Students will understand the benefits and limitations of animal cell culture.
Students will apply mathematical models to cell growth and product synthesis.
Students will identify, formulate, and solve problems related to the scale-up of biomanufacturing processes.
Students will design a biomanufacturing system, component, or process to meet desired needs.
Students will communicate effectively via a group setting about contemporary bio-manufacturing processes.
Topical Outline
1. Introduction to Animal Cell Biotechnology
2. Effective technical communication
3. Library instruction
4. Primary vs. immortalized cell lines
5. Cell metabolism, proliferation, and death in culture
6. Microcarrier culture
7. Adaptation to serum-free suspension culture
8. Animal cell bioreactors: Complications and considerations
