Course Description

The kinetics of drug absorption, distribution, and elimination with emphasis on the development and evaluation of mathematical models.

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Athena Title

PHARMACOKINETICS

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Prerequisite

Permission of department

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Semester Course Offered

Offered fall

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Grading System

A - F (Traditional)

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Course Objectives

1. Understand mathematical concepts used in pharmacokinetic compartmental modeling 2. Understand drug absorption,distribution and clearance concepts 3. Learn data fitting programs and how to interpret output from modeling 4. Design pharmacokinetic studies for clinical and animal experiments

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Topical Outline

Mathematical Methods for Pharmacokinetics Compartmental Models-IV Bolus Compartmental Models-Zero Order Input Compartmental Models-EV Input Compartmental Models Multiple Dosing Data Fitting-Winnonlin Noncompartmental Methods Distribution and Protein Binding Drug Transport Renal Clearance Biliary Clearance Absorption/Biopharmaceutics Bioavailability and Bioequivalence Hepatic Clearance Models Drug Metabolism Metabolite Kinetics Nonlinear Kinetics PBPK Modeling

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