Course Description
Designed to train students on three principal objectives that comprise the second and third stages of a drug discovery pipeline. Beyond its own course objectives, this course is the last of three two-hour course series that encompass aspects of the drug discovery pipeline.
Athena Title
Biopharmaceut & Pharmacokinet
Non-Traditional Format
This course will be taught 95% or more online.
Grading System
A - F (Traditional)
Course Objectives
1. What are biopharmaceutics and pharmacokinetics? 2. Will learn how to do non-compartment analysis (NCA) and compartment analysis through various administration routes, including oral and intrave. 3. Will gain experience in analyzing simulated PK data with WinNonLin, SimCyp, and GastroPlus. 4. Will learn how PK relates to the genetics, which is known as pharmacogenetics. 5. Will learn the principles of absorption, distribution, metabolism, and excretion (ADME) and to apply these principles to optimize a patient’s. 6. In terms of drug development, students will identify hypothetical drugs that have suitable PK properties for drug development.
Topical Outline
1. Pharmaceutics and Physiology 2. Fundamentals of Pharmacokinetics 3. IV Bolus Dose Administration 4. IV Infusion Administration 5. First Order Absorption 6. Drug Distribution 7. Renal Excretion 8. Hepatic Elimination 9. Relationship Between PK and Pharmacodynamics 10. Nonlinear Pharmacokinetics 11. Drug-drug Interactions 12. Disease/Age/Sex Effects on PK 13. Pharmacogenomics 14. Preclinical Evaluation 15. Clinical Evaluation