Regenerative bioscience approaches to tissue repair and regeneration, including stem cell therapies, biomaterials, tissue engineering, gene therapies, and cell manufacturing approaches in regenerative medicine. Students will also learn about how novel devices, technologies, and diagnostic tools can enhance regenerative medicine strategies.
Athena Title
Therapies for Tissue Repair
Prerequisite
RBIO 2010 and BIOL 1108
Semester Course Offered
Offered fall and spring
Grading System
A - F (Traditional)
Student learning Outcomes
In this course, students will learn about regenerative bioscience approaches to tissue repair and regeneration. Students will learn about endogenous repair processes and why limitations of endogenous repair processes necessitate the development of regenerative medicine strategies. This course will discuss therapeutic applications of stem cell therapies, biomaterials and tissue engineering, and gene therapy approaches in regenerative medicine. Students will also learn about how novel devices, technologies, and diagnostic tools can be used to enhance regenerative medicine strategies. Students will also gain scientific literacy skills by learning how to critically analyze and explain figures in scientific articles through in-class paper discussions.
Expected Learning Outcomes:
Students will explain the biological principles of tissue repair and regeneration, including endogenous repair processes and the limitations that motivate the development of regenerative medicine strategies.
Students will differentiate between the therapeutic mechanisms of stem cell-based therapies, tissue engineering scaffolds, and gene therapies used to treat specific organ pathologies.
Students will evaluate and compare the effectiveness of regenerative medicine therapies by considering mechanisms of action, therapeutic goals, and measures of success.
Students will critically evaluate scientific literature in regenerative bioscience by analyzing experimental approaches, interpreting figures and data, and assessing the effectiveness of regenerative medicine strategies.
Students will develop a formal scientific presentation that translates complex regenerative bioscience concepts using evidence-based arguments.
Topical Outline
· Biological mechanisms of tissue repair and regeneration, including mechanisms of vertebrate regeneration, cellular responses to injury, and limitations of endogenous repair processes.
· Tissue-specific repair and regenerative strategies, using skin, brain, skeletal muscle, and cardiac tissue as representative models of injury, repair, and regeneration.
· Cell-based and tissue engineering approaches to regeneration, including somatic and stem cell therapies, extracellular vesicles, biomaterials, scaffolds, and 3D tissue engineering strategies.
· Advanced regenerative medicine technologies, including cell engineering, gene therapy and gene editing, nanoparticles, bioreactors, organ-on-chip systems, and regenerative medicine devices.
· Translation and commercialization of regenerative medicine therapies, including cell manufacturing, preclinical and clinical development, regulatory considerations, ethical challenges, and pathways for bringing regenerative medicine products to market.
