Course Description
Reading and discussion of current topics in skeletal muscle biochemistry and oxygen transport relating to exercise. Topics will include contractile protein energetics, ATP production pathways, blood flow to muscle, and oxygen delivery. Emphasis will be placed on acute changes with exercise, and plasticity of skeletal muscle in response to increases and decreases in physical activity.
Athena Title
MUSCLE ENERGETICS
Equivalent Courses
Not open to students with credit in EXRS 8420
Prerequisite
[KINS 7330-7330L and (VPHY 6090 or PHRM 6500) ] or permission of department
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
Students will be able to: Discuss the sources of energy utilization in skeletal muscle, including the cross-bridge cycle and the role of ATP. Discuss the basic biochemical pathways of substrate utilization as it pertains to exercising skeletal muscle. Discuss metabolic control of oxidative and glycolytic metabolism in exercising skeletal muscle. Discuss the basic pathways by which altering activity level alters gene expression in skeletal muscle. Discuss the role of external respiration on limiting exercise capacity. Discuss the role of cardiac function on limiting exercise capacity. Discuss the role of blood volume, blood hemoglobin concentrations of exercise capacity. Discuss the role of peripheral arteries on the delivery of oxygen and on limiting exercise capacity. Discuss the role of capillaries (microcirculation) on delivery of oxygen and metabolic exchange in skeletal muscle. Discuss the role of veins and lymph systems on exercise capacity. Discuss the transport of oxygen from blood to mitochondrial and the role of this exchange on limiting exercise exercise capacity.
Topical Outline
Respiration and exercise performance Cardiac function and exercise Arterial physiology and exercise Capillary function in skeletal muscle Veins and lymph system during exercise Oxygen exchange from capillaries to muscle mitochondria Control and plasticity of oxidative metabolism Control and plasticity of glycolysis