Course Description
Provides an in-depth look at selected aspects of the innate
immune response, including the cellular and molecular
components critical to its development. The course will focus
on fundamental discoveries and recent advances. Some selected
topics will include Toll-like receptor signaling, the
inflammasome, neutrophil NETosis, dendritic cells as antigen
presenting cells, newly identified innate cell types, and
innate immunity in disease.
Athena Title
Advanced Immun Innate Immunity
Prerequisite
Permission of department
Pre or Corequisite
CBIO(MIBO)(IDIS) 4100/6100
Semester Course Offered
Offered spring
Grading System
A - F (Traditional)
Student learning Outcomes
- 1. Describe the major cellular and molecular components of the innate immune system, antigen presentation by dendritic cells, innate immune cell recruitment and functions, and critical pathways, including Toll-like receptor signaling, cytosolic sensors of PAMPs and DAMPs, the inflammasome, and neutrophil extracellular traps (NETs).
- 2. Critically evaluate primary research articles by summarizing key findings, assessing methodological limitations, and contextualizing the work's contribution to the field.
- 3. Integrate knowledge from multiple disciplines and diverse scientific backgrounds to formulate novel, testable hypotheses that address meaningful research questions.
- 4. Collaborate productively as part of a research team to develop and refine scientific ideas and present them effectively in an oral format.
Topical Outline
- Innate Immune Sensors: TLRs, NLRs, & inflammasomes; RLRs and DNA sensors
- Antioxidant systems and Redox control: cellular sources of ROS; antioxidants and their regulation
- Neutrophils in innate immunity
- Mucosal Innate Immunity: innate immunity at mucosal sites; immunity at specific mucosal surfaces
- Immunometabolism: overview and immune cell phenotypes; immunometabolism and diseases
- Trained Immunity: overview and mechanisms
