Course Description
The molecular mechanisms of gene action in procaryotes and eucaryotes, including discussions of chromosome structure and replication, mutagenesis and DNA repair, recombination mechanisms, transposition, transcriptions, and translation controls.
Athena Title
ADV MOL GN
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Course Objectives
Students will master topics in advanced molecular genetics through lectures by research faculty and through reading and discussion of selected research papers from the primary literature. The successful student will understand general concepts and mechanisms of molecular genetics, as well experimental approaches used in contemporary molecular genetics research. The successful student will understand how to formulate and test hypotheses drawn from concepts of molecular genetics, and be able to understand, interpret and evaluate published experimental data. Students will be evaluated on the basis of written examinations and participation in class discussions.
Topical Outline
1. Transcriptional regulation - prokaryotes 2. Yeast genetics 3. Cell cycle - yeast 4. Meiosis - yeast 5. Yeast mating type switching 6. Prions 7. RNA splicing - eukaryotes 8. RNA localization - eukaryotes 9. Posttranscriptional regulation - eukaryotes 10. Cell-cell signaling 11. Behavioral genetics 12. Cell cycle 13. Plant genetics 14. Gene silencing and position effects - plants 15. Co-suppression - plants 16. Mammalian genetics - genome mapping 17. Manipulating the mouse genome 18. Genetic modifiers 19. Gene expression and chromatin structure 20. Gene silencing and position effects - flies and mice The course syllabus is a general plan for the course; deviations announced to the course by the instructor may be necessary.