Vertebrate endocrinology and the principals of long-distance communication between organs through the production of hormones. Experimental animal models will be used to explore the cellular and molecular mechanisms of hormone action. Topics will include whole body homeostasis, sexual development, sexual function, aging and diseases caused by misregulation of hormone production.
Athena Title
Medical Endocrinology
Prerequisite
[(BIOL 1103 and BIOL 1103L) or BIOL 1107-1107L or BIOL 2107H-2107L] and [(BIOL 1104 and BIOL 1104L) or BIOL 1108-1108L or BIOL 2108H-2108L]
Semester Course Offered
Offered fall
Grading System
A - F (Traditional)
Student learning Outcomes
At the end of the semester, students will know the gross histology and anatomy of the endocrine system.
At the end of the semester, students will understand the genetic and molecular regulatory mechanisms of hormone production and hormone mediated intercellular communication.
At the end of the semester, students will learn how to analyze primary literature.
At the end of the semester, students will be able to work in collaborative groups to apply concepts in endocrinology to real-life situations, presented as case studies.
At the end of the semester, students will demonstrate appropriate written and oral science communication skills.
Topical Outline
Introduction; What is endocrinology? Classification of hormones
Hormone synthesis, transport & feedback regulation
How does a hormone exert its effects? Membrane receptors: G
proteins
Catalytic (kinase linked) receptors; Intracellular receptors
Multiple organ effects
Mechanisms of disease
Endocrine Pancreas: Insulin
Energy metabolism & diabetes mellitus
GI hormones
Receptor kinetics
Calcitonin & Vitamin D
Regulation of Ca2+ and PO4
Vasopressin (Antidiuretic Hormone)
AVP & water balance
Aldosterone & AVP: Sodium & water balance
Hormonal control of blood pressure
Sexual differentiation
Human Reproduction
Endocrine Overview
Receptors
Immunoassays
Endocrine Biosynthesis
Pancreas
Gastrointestinal Endocrinology
Adrenal Medulla
Adrenal Cortex
Thyroid
Calcium and Bone Physiology
Parathyroid
Sodium and Water Regulation
Neurohypophysis
Renin-Angiotensin System
Sex Differentiation and Puberty
Male Reproduction
Female Reproduction
Pregnancy and Lactation
Infertility
The course syllabus is a general plan for the course;
deviations announced to the class by the instructor may be
necessary.
