Course Description
Fundamentals of physical pharmacy and pharmaceutical dosage form design.
Additional Requirements for Graduate Students:
Graduate students will be required to write a term paper in the
research area of pharmaceutics. In addition, graduate students
are expected to read more extensively than the professional
students using the reading list provided by the instructor.
Graduate student exams will be based on the latter, as well as
normal course requirements, and will be more challenging
than the professional student exam.
Athena Title
Fundamentals Pharmaceutics I
Corequisite
PHRM 4030
Semester Course Offered
Offered every year.
Grading System
A - F (Traditional)
Course Objectives
To provide the student with a fundamental knowledge of pharmaceutical and biopharmaceutical concepts and principles as they apply to the development and assessment of various types of drug delivery systems and dosage forms for the practice of pharmacy. The course will attempt to emphasize critical thinking and problem solving. However, some rote memorization is unavoidable. Upon completion of the course, the student should be able to: 1. To understand the basic physical pharmacy concepts in physical states of matter, ionic equilibria, buffers, solubility, partitioning, drug stability, etc. These principles are important for the rational design of pharamceutical dosage forms. 2. Understand the roles of drug delivery, different delivery systems and dosage forms in pharmacotherapeutics. 3. Comprehend the theoretical and practical pharmaceutical skills necessary for the formulation, production, and quality control of classical and modern pharmaceutical dosage forms. 4. Utilize kinetic methods to determien drug stability, shelf-life and storage requimrents of drug products. 5. Explain the importance of the bioavailability and bioequivalence of drug products for treating diseases and generic substitution. 6. Develop the scientific skills to evaluate drug delivery and delivery systems so as to be able to exercise critical judgment and offer specific recommendations to physicians and patients for optimizing drug therapy.
Topical Outline
Introduction - Course Objectives Drug Development Process Physical States of Drugs and Phase Equilibria Fundamentals of Thermodynamics Solutions of Nonelectrolytes and Electrolytes Qualitative Aspects of Drug Acidity/Basicity Acid/Base Properties of Drugs Quantitative aspects of drug acidity/basicity Quantitative Aspects of pH Relating to Solubility and Partitioning Buffering, Buffers in Pharmaceutics Solubility, Salts and Pharmaceutical Solutions Chemical Kinetics, Drug Degradation & Stability Bioequivalence Drug Delivery Systems Preformulation Studies Solid Dosage Forms Sustained/Controlled Release Formulations Oral - Liquids Emulsions & Surfactants Semisolids Nasal/Ocular/Pulmonary - Drug Delivery Parenterals Sterility - Microbiological Transdermal Drug Delivery Biotech Products Novel Drug Delivery Systems
Syllabus
Public CV