| Course ID: | PBGG(CRSS)(HORT)(PBIO) 8875. 1 hour. |
| Course Title: | Genome-wide Association in Plants |
Course
Description: | The methods, design, and implementation of genome-wide
association studies (GWAS) to map genetic loci in crop plants.
We will discuss the theory and history of genome-wide
association, parameters that affect its power and accuracy, and
practical considerations for carrying it out. |
| Oasis Title: | Genome-wide Association Plants |
| Prerequisite: | PBGG(CRSS)(HORT)(PBIO) 8871 or PBGG(CRSS)(HORT)(PBIO) 8872 or PBGG(CRSS)(HORT) 8874 or permission of department |
| Pre or Corequisite: | PBGG(CRSS)(HORT)(PBIO) 8871 or PBGG(CRSS)(HORT)(PBIO) 8872 or PBGG(CRSS)(HORT) 8874 or permission of department |
Semester Course
Offered: | Offered spring semester every odd-numbered year. |
| Grading System: | A-F (Traditional) |
|
| Course Objectives: | The objective will be for students to learn methods, design, and
implementation of genome-wide association studies to map genetic
loci in crop plants.
Learning objectives:
1. Understand the theory behind genome-wide association and how
to design a GWAS experiment with plants.
2. Know the various parameters that can influence the power and
resolution of GWAS and how the experimenter can adjust them.
3. Be able to perform GWAS using both generalized and mixed
linear models, including the use of covariates population. |
| Topical Outline: | Background on association analysis and GWAS
Considerations of a GWAS experiment
Population size
Trait architecture
Genotyping density and linkage disequilibrium decay
GWAS algorithms & components
Generalized linear models
Mixed linear models
Population structure and kinship
GWAS variants (logistical regression, NAM/MAGIC populations,
etc.)
Software for GWAS analysis |