| Course ID: | PMCY 6430E. 2 hours. |
| Course Title: | Biopharmaceutics and Pharmacokinetics |
Course
Description: | Designed to train students on three principal objectives that
comprise the second and third stages of a drug discovery pipeline.
Beyond its own course objectives, this course is the last of three
two-hour course series that encompass aspects of the drug
discovery pipeline. |
| Oasis Title: | Biopharmaceut & Pharmacokinet |
| Nontraditional Format: | This course will be taught 95% or more online. |
| Grading System: | A-F (Traditional) |
|
| Course Objectives: | 1. What are biopharmaceutics and pharmacokinetics?
2. Will learn how to do non-compartment analysis (NCA) and
compartment analysis through various administration routes,
including oral and intrave.
3. Will gain experience in analyzing simulated PK data with
WinNonLin, SimCyp, and GastroPlus.
4. Will learn how PK relates to the genetics, which is known as
pharmacogenetics.
5. Will learn the principles of absorption, distribution,
metabolism, and excretion (ADME) and to apply these principles
to optimize a patient’s.
6. In terms of drug development, students will identify
hypothetical drugs that have suitable PK properties for drug
development. |
| Topical Outline: | 1. Pharmaceutics and Physiology
2. Fundamentals of Pharmacokinetics
3. IV Bolus Dose Administration
4. IV Infusion Administration
5. First Order Absorption
6. Drug Distribution
7. Renal Excretion
8. Hepatic Elimination
9. Relationship Between PK and Pharmacodynamics
10. Nonlinear Pharmacokinetics
11. Drug-drug Interactions
12. Disease/Age/Sex Effects on PK
13. Pharmacogenomics
14. Preclinical Evaluation
15. Clinical Evaluation |
| Honor Code Reference: | All academic work must meet the standards contained in “A Culture
of Honesty," the University of Georgia’s policies on Academic
Honesty (http://honesty.uga.edu). |