| Course ID: | EHSC 8550. 3 hours. |
| Course Title: | Developmental and Reproductive Toxicology |
Course
Description: | Topics will include developmental and reproductive processes;
how chemical, biological, or physical agents disrupt normal
processes; experimental approaches to evaluating suspected
teratogens; and mechanisms for how exposure to agents results
in reproductive or developmental abnormalities. Class will
include a combination of lecture, case studies, and critical
discussions of primary literature. |
| Oasis Title: | DEVELOP REPROD TOX |
| Prerequisite: | PHRM(VPHY) 6910 or EHSC 4490/6490 or permission of department |
Semester Course
Offered: | Offered spring semester every odd-numbered year. |
| Grading System: | A-F (Traditional) |
|
| Course Objectives: | This course is intended for graduate students at any level with
an interest in developmental and reproductive toxicology.
By the end of the course, the students will be able to:
- Describe the basic principles of how toxicants can adversely
impact developmental and reproductive processes
- Describe experimental approaches to evaluate agents for
developmental and reproductive impacts
- Discuss the significance, reliability and interpretation of
developmental and reproductive toxicity studies in animals
- Critically evaluate published/peer reviewed literature
- Participate in open discussion about mechanisms, case
reports and other special topics presented to class. |
| Topical Outline: | Outline will vary according to the most recent scientific
publications in the area of developmental and reproductive
toxicology. The following is a summary for common topics to be
covered each class offering.
- Basic principles of developmental and reproductive toxicology
- Mechanisms of abnormal development
- Identification of birth defects and reproductive toxicants
- Experimental design of reproductive and developmental studies
- Endocrine disrupting chemicals
- Chemicals that result in abnormal birth outcomes
- Infections that increase birth defects
- Predictors of abnormal birth outcomes: molecular biology,
chemical structures/activity relationships, bioinformatics
- Maternally- and paternally mediated effects on development
- Developmental and reproductive toxicity risk assessment
- Case studies in reproductive and developmental toxicants and agents |